Kinneret Keren, Technion, Israel Institute of Technology, Haifa, Israel (O-002)
The interplay between actin dynamics and membrane tension determines the shape of moving cells
Globe Hall

Chair: Michael A. Ferenczi, London, UK

Invited speakers:
Sarah Cianferani, Strasbourg, France (O-025)
Native mass spectrometry to decipher interactions between biomolecules

Jelle Hendrix, Leuven, Belgium (O-046)
Visualizing and quantifying HIV-host interactions with fluorescence microscopy

Short talks:
Stephan Grage, Kahlsruhe, Germany (O-043)
Crowding of membrane proteins and peptides

Pietro Parisse, Trieste, Italy (O-073)
Enzymatic reactions in nanostructured surfaces: unzipping and cutting the double helix

Masahide Terazima, Kyoto, Japan (O-096)
Time-resolved detection of protein-protein interaction

Anna Wypijewska, Warsaw, Poland (O-107)
Experimental physics resources for studying biological macromolecules; deep insight into DcpS enzymatic hydrolysis of short capped mRNAs

László Smeller, Budapest, Hungary (O-090)
Unfolding of the cod parvalbumin Gad m1 allergen by high pressure

Invited speakers:
Thomas Knöpfel, Wako, Japan (O-111)
Optogenetic electrophysiology

Máté Lengyel, Cambridge, UK (O-118)
Neuronal biophysics: optimised for information processing?

Zoltán Nusser, Budapest, Hungary (O-120)
Subcellular compartment-specific distribution of voltage-gated ion channels

Short talks
Emily Ferenczi, Stanford, USA (O-114)
Opsin stability under varying stimulation conditions

Martin Kopani, Bratislava, Slovakia (O-117)
Hematite particles in human brain

Joanna Mattis, Stanford, USA (O-119)
An analysis of new and existing opsins for scientific application

Invited speakers
Niall Macquaide, Leuven, Belgium (O-126)
High sensitivity of Ca²⁺ wave propagation to ryanodine receptor inhibition in cardiac myocytes

Francesco Zorzato, Ferrara, Italy (O-131)
Calcium influx analysis by TIRF microscopy on myotubes from patients with RYR1 mutations linked to MH and CCD

Ernst Niggli, Bern, Switzerland (O-127)
Alterations of ryanodine receptor (RyR) function and arrhythmogenic Ca²⁺ waves in cardiomyocytes

László Csernoch, Debrecen, Hungary (O-130)
Caffeine and depolarization alters the morphology of calcium spark in amphibian skeletal muscle

Short talk
Dirk Gillespie, Chicago, USA (O-125)
A simple model to describe single and multichannel calcium regulation of ryanodine receptors

Holger Stark, Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany (O-003)
Structure determination of dynamic macromolecular complexes by single particle cryo-EM
Globe Hall

Chair: Erick J. Dufourc, Bordeaux, France

Invited speakers
Didier Marguet, Marseille, France (O-188)
Spot variable Fluorescence Correlation Spectroscopy reveals fast scouting of K-Ras at the plasma membrane of living cells

Christian Eggeling, Göttingen, Germany (O-142)
Imaging membrane heterogeneities and domains by super-resolution STED nanoscopy

Petra Schwille, Dresden, Germany (O-182)
Minimal systems for membrane associated cellular processes

Short talks
Nicolas Destainville, Toulouse, France (O-139)
Role of long-range effective protein-protein forces in the formation and stability of membrane protein nano-domains

Erick Dufourc, Bordeaux, France (O-141)
Magnetic camemberts and liposomes: New tools for structural biology of membrane molecules

Nicky Ehrlich, Copenhagen, Denmark (O-143)
Ca²⁺ controlled all-or-none like recruitment of synaptotagmin-1 C2AB to membranes

Invited speakers
Tuomas Knowles, Cambridge, UK (O-200)
Kinetics of protein aggregation

Sara Linse, Lund, Sweden (O-205)
Mechanistic insights into Aß42 aggregation and effects of inhibitors

Short talks
Martino Calamai, Florence, Italy (O-192)
Amyloid-like aggregates alter the membrane mobility of GM1 gangliosides

Sylvie Noinville, Paris, France (O-208)
Membrane permeabilization by purified soluble beta-enriched oligomers of prion protein

Anja Stefanovic, Twente, The Netherlands (O-213)
Mechanistic insights into oligomeric alpha-synuclein/membrane interactions

Annelies Vandersteen, Brussels, Belgium (O-218)
Biophysical consideration of gamma-secretase modulation as potential target for Alzheimer's disease

Bojan Zagrovic, Vienna, Austria (O-219)
Microscopic analysis of protein oxidative damage: effect of carbonylation on structure, dynamics and aggregability of villin headpiece

Invited speakers
Antoine van Oijen, Groningen, The Netherlands (O-238)
Single-molecule studies of DNA replication

Jean-Marc Victor, Paris, France (O-239)
In silico single molecule manipulation with rigid body dynamics: an efficient tool for modeling the mechanical properties of DNA-protein complexes

Short talks
Vera Böhm, Heidelberg, Germany (O-225)
Nucleosome accessibility investigated using single molecule fluorescence

Péter Brazda, Debrecen, Hungary (O-226)
Dissecting the role of coregulator exchange and chromatin binding in retinoic acid receptor (RAR) mobility by live cell FCS

Nikolay Korolev, Singapore, Republic of Singapore (O-230)
Chromatin condensation: general polyelectrolyte association and histone-tail specific folding

Carlo Manzo, Castelldefels (Barcelona), Spain (O-232)
Lambda genetic switch sensitivity depends on complex looping kinetics driven by nonspecific binding

Jeff Stear, Berlin, Germany (O-236)
DNA replication machinery clamps down on chromatin mobility

Chair: László Mátyus, Debrecen, Hungary

Invited speakers
Andrea Vaiana, Göttingen, Germany (O-310)
Molecular dynamics simulations of ribosomal translocation based on Cryo-EM data

Nir Ben-Tal, Tel Aviv, Israel (O-247)
Using low-resolution structural data to model structure, function and motion in transmembrane proteins

Short talks
Lennart Nilsson, Stockholm, Sweden (O-286)
Nucleotide modifications and tRNA anticodon- mRNA codon interactions on the ribosome

Stefano Piana-Agostinetti, New York, USA (O-293)
The quest for the perfect force field

Tatjana Skrbic, Trento, Italy (O-302)
The role of non-native interactions in knotted proteins

András Szilágyi, Budapest, Hungary (O-308)
Segment swapping between domains is an evolutionary mechanism that generates new protein folds

Ilpo Vattulainen, Tampere, Finland (O-313)
Trafficking of lipids between high density lipoprotein and cholesteryl ester transfer protein

Invited speakers
Alberto Diaspro, Genoa, Italy (O-329)
Optical nanoscopy and individual molecule localization with focused light under linear and non linear regimes

Werner Kühlbrandt, Frankfurt, Germany (O-341)
Cryo-EM of membranes and membrane proteins

Short talks
Donna J. Arndt-Jovin, Göttingen, Germany (O-321)
Programmable Array Microscope imaging of living cells and spin-off to tumor diagnostics

Virginijus Barzda, Toronto, Canada (O-322)
Three-dimensional video-rate nonlinear microscopy of contracting myocytes

Benjamien Moeyaert, Leuven, Belgium (O-343)
Rational design and applications of photoconvertible and bi-photochromic fluorescent proteins

Vinod Subramaniam, Twente, The Netherlands (O-349)
Integrin-dependent activation of the JNK signaling pathway in live cells by mechanical stress

Thomas van Zanten, Barcelona, Spain (O-350)
Direct mapping of nanoscale compositional connectivity on intact cell membranes

Invited speakers
Toshio Yanagida, Osaka, Japan (O-369)
Switch between large hand-over-hand and small inchworm-like steps in myosin VI

Anne Houdusse, Paris, France (O-360)
How myosin traps and how actin triggers the release of phosphate at the beginning of force generation

Short talks
Marco Capitanio, Florence, Italy (O-354)
Myosin on an optical leash: Load dependence of the working stroke in a single myosin head

Ryohei Chiwata, Tokyo, Japan (O-356)
Rotation of F1-ATPase with a protrusion-less gamma rotor

Michael Kolbe, Göttingen, Germany (O-361)
Assembly and function of the type 3 secretion system needle from Salmonella typhimurium

Anna Roujeinikova, Victoria, Australia (O-366)
Mechanism of the force generation in the bacterial flagellar motor: a structural biology perspective

Andrej Vilfan, Ljubljana, Slovenia (O-368)
Longitudinal and rotational motion of microtubules driven by the kinesin-14 motor ncd

Ferenc Mezei, Research Institute for Solid State Physics and Optics, Budapest, Hungary (O-305)
Spectroscopic explorations of the nature of protein dynamics
Globe Hall

Chair: J. Antoinette Killian, Utrecht, The Netherlands

Invited speakers
Malcolm Walkinshaw, Edinburgh, UK (O-408)
Structural and biochemical studies show divergent allosteric mechanisms in glycoytic enzymes

Susan Lea, Oxford, UK (O-393)
Structural insights into the control of type three secretion

Short talks
Tuomo Glumoff, Oulu, Finland (O-382)
Structure-function relationships in different MFE-2 proteins by various biophysical techniques

Tommi Kajander, Helsinki, Finland (O-389)
The structure of factor H in complex with C3d explains regulation of immune complement alternative pathway

Anthony Wilkinson, York, UK (O-410)
Structure of an Intercellular Channel Formed during Sporulation in Bacillus subtilis

Johann Klare, Osnabrück, Germany (O-392)
Conformational changes during GTPase activity induced self-assembly of human guanylate binding protein 1 revealed by EPR spectroscopy

Invited speakers
Tom Jovin, Göttingen, Germany (O-425)
FRET approaches to signal transduction: from QD biosensors to live-cell EGFR signaling

Ranieri Bizzarri, Pisa, Italy (O-416)
Engineering the excited state of fluorophores for high resolution imaging of bio- and soft-matter

Short talks
Ana Morales Garcia, Sheffield, UK (O-430)
SFM study of bacterial cell walls

Marina Kuimova, London, UK (O-427)
Measuring intracellular viscosity: from molecular rotors to Photodynamic Therapy of cancer

Andrew Shevchuk, London, UK (O-434)
Multifunctional ion conductance microscopy for biophysical studies at nanoscale

Markus Staufenbiel, Osnabrück, Germany (O-437)
Triple-colour super-resolution imaging in living cells

Stephen Webb, Harwell, UK (O-438)
Simultaneous, multicolour single molecule imaging of the entire ErbB receptor family in live cells

Invited speakers
Hans Frauenfelder, Los Alamos, USA (O-444)
Protein dynamics explored by Mössbauer effect and neutron scattering

Maikel Rheinstädter, Hamilton, Canada (O-449)
Nanobiology: Membranes and proteins in motion

Short talks
Ralf Biehl, Jülich, Germany (O-440)
Function of Phosphoglycerate Kinase enabled by large domain movements

Alexandre Chenal, Paris, France (O-441)
Deciphering membrane insertion of the diphtheria toxin translocation domain

Christine Ebel, Grenoble, France (O-442)
Fluorinated surfactants (FSs) for studying membrane proteins (MPs)

Stéphane Longeville, Gif-sur-Yvette Cedex, France (O-447)
Influence of macromolecular crowding on protein stability

Andreas Stadler, Jülich, Germany (O-451)
Thermal fluctuations of hemoglobin from different species

Ernst Bamberg, Department of Biophysical Chemistry, Max-Planck -Institute of Biophysics, Frankfurt (O-006)
Microbial Rhodopsins: Light-gated ion channels and pumps as optogenetic tools in neuro- and cell biology
Globe Hall

Chair: Alberto Diaspro, Genoa, Italy

Invited speakers
Christoph Schmidt, Göttingen, Germany (O-472)
Control of the fast, slow and reverse gear of the yeast mitotic kinesin-5 Cin8

Josef Alfons Käs, Leipzig, Germany (O-463)
Are biomechanical changes necessary for tumor progression?

Paul Janmey, Philadelphia, USA (O-459)
Driving cytoskeletal remodeling by extracellular matrix mechanics

Short talks
Beáta Bugyi, Pécs, Hungary (O-481)
Tropomyosin isoform specific regulation of nucleation factors

Siddharth Deshpande, Basel, Switzerland (O-453)
Dynamics of Confined Actin Networks in Microchambers

Pierre Recouvreux, Amsterdam, The Netherlands (O-470)
Automated image analysis of microtubule dynamics and maintenance of fission yeast cells morphology

Invited speakers
Bernard Attali, Tel Aviv, Israel (O-483)
Targeting the promiscuous voltage sensor of voltage-gated cations channels by novel gating-modifiers

Declan Doyle, Dublin, Ireland (O-486)
Over-expression of human ion channels and transporters for structural studies

Short talks
Aura Jimenez, Mexico City, Mexico (O-491)
Effect of cholesterol and cytoskeleton on KV10.1 membrane distribution

Péter Lukács, Vienna, Austria (O-495)
Differential modulation of inactivated states by hydrophilic and hydrophobic sodium channel blockers

Lubica Lacinova, Bratislava, Slovakia (O-494)
Gating currents of low-voltage-activated T-type calcium channels family

Tibor Szántó G., Debrecen, Hungary (O-502)
Molecular rearrangements during slow inactivation of the Shaker-IR potassium channel

Ligia Toro, Los Angeles, USA (O-506)
Molecular characterization of BK_Ca channel in cardiac mitochondria

Invited speakers
Holger Dau, Berlin, Germany (O-515)
Photosynthetic water oxidation: From biophysics to solar fuels

Rienk van Grondelle, Amsterdam, Netherlands (O-534)
Excitation energy transfer and non-photochemical quenching in photosynthesis

Péter Maróti, Szeged, Hungary (O-527)
Relaxation of bacteriochlorophyll fluorescence in intact cells of photosynthetic bacteria

Short talks
László Kálmán, Montreal, Canada (O-523)
Effect of hydrophobic mismatch on the light-induced structural changes in bacterial reaction centers

Jidnyasa Joshi, Frankfurt am Main, Germany (P-522)
Characterization of the light harvesting antenna system in the diatom Phaeodactylum tricornutum

Gert Schansker, Szeged, Hungary (O-530)
Variable chlorophyll fluorescence: in part a yield change due to light-induced conformational change

Invited speakers
Janos K. Lanyi, Irvine, USA (O-545)
Proton transfers in a light-driven proton pump

Jochen Blumberger, London, UK (O-537)
Computational Bioenergetics: From pure electron transfer in mono- and multi-heme cytochromes to chemistry in catalases

Short talks
Dimitri Khoshtariya, Tbilisi, Georgia (O-544)
Mechanistic insights for redox-active proteins functionalized at Au/SAM junctions

Manuela Pereira, Lisbon, Portugal (O-548)
Sodium influence on energy transduction by bacterial complexes I

Andrei Pisliakov, Tokyo, Japan (O-549)
Mechanism of proton transfer in nitric oxide reductase: computational study

Ivo Saraiva, Oeiras, Portugal (O-552)
Molecular characterization of photosynthetic iron oxidation

László Zimányi, Szeged, Hungary (O-557)
Characterization of a vacuolar cytochrome b561 by redox titration and spectrum analysis

Invited speakers
Kenji Okuse, London, UK (O-568)
Clustering of voltage-gated sodium channel Nav1.8 in lipid rafts is essential for action potential propagation in nociceptive unmyelinated axons

David Beech, Leeds, UK (O-562)
Calcium channels of vascular remodelling

Annarosa Arcangeli, Florence, Italy (O-558)
hERG1 channels: from antitargets to novel therapeutic targets in oncology.

Short talks
András Balajthy, Debrecen, Hungary (O-559)
Analysis of the K⁺ current in human T cells in hypercholesterinaemic state

Karlheinz Hilber, Vienna, Austria (O-565)
Voltage-gated ion channel dysfunction precedes cardiomyopathy development ion the dystrophic heart

Ildikó Szabó, Padua, Italy (O-572)
Membrane-permeant inhibitors of the potassium channel Kv1.3 induce apoptosis in cancer cell lines

Invited speakers
Mark Howarth, Oxford, UK (O-582)
Get a grip: engineering ultra-stable interactions to proteins for biophysics and medicine

Florian Lesage, Valbonne, France (O-580)
Background K⁺ channel gating and cell excitability

Pál Ormos, Szeged, Hungary (O-590)
Hydrodynamic synchronisation of light driven microscopic rotors

Andrew Turberfield, Oxford, UK
Protein structure by cryo-EM using DNA-templated protein arrays

Short talk
Károly Osvay, Szeged, Hungary (O-589)
Towards attosecond biophysics: what can ELI-ALPS offer?

Michael Grätzel, Laboratory of Photonics and Interfaces, Institute of Chemical Science and Engineering, Station 6, Ecole Polytechnique Fédérale, Lausanne, Switzerland, (O-008)
Molecular photovoltaics mimic photosynthesis
Globe Hall

Chair: Anthony J. Wilkinson, York, UK

Invited speakers:
Derek Marsh, Göttingen, Germany (O-624)
Biophysics of membrane lipidomics

Gerhard Schütz, Linz, Austria (O-591)
Single molecule biology - Studying meetings within the plasma membrane

Timothy A. Cross, Tallahassee, USA (O-592)
The native M2 proton channel structure from Influenza A

Short talks
Gregor Anderluh, Ljubljana, Slovenia (O-596)
Perforin induces invaginations in model membranes

Georg Pabst, Graz, Austria (O-631)
Stereo-specific effect of the analgesic drug ketamine on lipid membranes

Horia Petrache, Indianapolis, USA (O-632)
Dependence of gramicidin A channel lifetime on membrane structure obtained from x-ray scattering measurements

Invited speakers:
Peter Wright, La Jolla, USA (O-667)
Promiscuous liaisons: functional interactions of intrinsically disordered proteins in biological signaling

Mónika Fuxreiter, Budapest, Hungary (O-651)
Fuzziness in protein-DNA interactions: beyond what can be seen

Short talks
Mónika Bokor, Budapest, Hungary (O-645)
Wide-line NMR and relaxation characterization of interfacial water in protein solutions

Karin Hauser, Konstanz, Germany (O-653)
Folding rates studied by a combination of static and time-resolved infrared spectroscopy

Julien Roche, Montpellier, France (O-659)
Probing cavities in SNase structure: a high pressure NMR study

Clemens Sill, Jülich, Germany (O-662)
Lactoferrin: Dynamics of a flexible protein in solution revealed by neutron scattering

Carine van Heijenoort, Gif-sur-Yvette, France (O-665)
How scarce sequence elements control the function of single ß-thymosin/WH2 domains in actin assembly

Invited speakers:
Ewa Paluch, Dresden, Germany (O-676)
Polar actin cortex mechanics and cell shape stability during cytokinesis

Fernando Peruani, Dresden, Germany (O-677)
Transition to collective motion in bacterial colonies

Roberto Mayor, London, UK (O-673)
Collective migration of neural crest cells: a balance between repulsion and attraction

Short talks
Előd Méhes, Budapest, Hungary (O-674)
Pattern formation by collective cell migration-driven segregation

Agnes Miermont, Paris, France (O-675)
Signaling cascade dynamics after a hyper-osmotic shock in the yeast Saccharomyces cerevisiae

András Czirók, Budapest, Hungary (O-668)
Vasculogenesis and collective movement of endothelial cells

Invited speakers:
Ahmet Yildiz, Berkeley, USA (O-714)
Cytoplasmic dynein moves through uncoordinated action of the AAA+ ring domains

Nynke Dekker, Delft, The Netherlands (O-686)
Single-molecule torque spectroscopy for biophysical investigations

Short talks
Pasquale Bianco, Florence, Italy (O-680)
Millisecond-piconewton force steps reveal the kinetics of DNA overstretching

Nunilo Cremades, Cambridge, UK (O-685)
Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein

Rony Granek, Beersheba, Israel (O-688)
Protein dynamics and stability: Universality vs. specificity

Changjiang You, Osnabrück, Germany (O-715)
Self-controlled monofunctionalization of quantum dots and their applications in studying protein-protein interaction in live cells

Carolina Carrasco, Madrid, Spain (O-684)
Magnetic Tweezers studies of AddAB: a molecular motor for repairing broken DNA

Invited speakers:
Klaus Fendler, Frankfurt, Germany (O-727)
SSM-based electrophysiology: Transport mechanism and pH-regulation of the Na⁺/H⁺ antiporter NhaA from E. coli

Francesco Valle, Bologna, Italy (O-752)
Multiscale pattern fabrication for life-science applications

Joachim Heberle, Berlin, Germany (O-730)
Surface-Enhanced InfraRed Absorption Spectroscopy (SEIRAS) of membrane protein monolayers

Short talks
Péter Galajda, Szeged, Hungary (O-728)
Swimming motility of bacteria near solid surfaces

Daniel Horak, Praha, Czech Republic (O-732)
Multifunctional magnetic nanoparticles for cell imaging

Kate Poole, Berlin, Germany (O-745)
Defining the forces required to gate mechanosensitive channels in mammalian sensory neurons

Invited speakers:
Gábor Forgács, Columbia, USA (O-762)
Organ printing: the key to eternal life?

Loredana De Bartolo, Rende, Italy (O-758)
Membrane biohybrid systems for tissue and organ engineering

Short talks
Olivia Berthoumieu, Oxford, UK (O-756)
Engineered bacteriorhodopsin: a molecular scale conductance photoswitch

Etienne Loiseau, Montpellier, France (O-769)
Continuous droplet interface crossing encapsulation for high through-put monodisperse vesicle design

Elisa Migliorini, Trieste, Italy (O-770)
Acceleration neuronal precursors differentiation induced by substrate nanotopography

Adél Muskotál, Veszprém, Hungary (O-771)
A polymerizable GFP variant

Anna Tugarova, Saratov, Russia (O-777)
FTIR spectroscopic study of biopolyester synthesis traits in the bacterium Azospirillum brasilense

Akihiro Kusumi, Institute for Integrated Cell-Material Sciences (iCeMS), Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan (O-009)
Organizing principle of the plasma membrane: three-tiered meso-scale domain architecture revealed by single-molecule tracking
Globe Hall

Chair: Attila Jenei, Debrecen, Hungary